Local gas flow-volume loops

Local gas flow-volume loops


V|LF-Spiro3D aims at developing and validating a new modality for spatially resolved, 3D lung structure and function characterization using cost-effective small-footprint, low and very-low MRI technology. 3D MR spirometry is to provide an accessible tool for the early diagnosis, staging, and treatment follow-up of patients suffering from respiratory diseases.


Lung function is a central concern in the fight against covid-19. Beyond the pandemic heavy losses and long-term health implications, respiratory diseases represent a major threat for the World Health Organisation. It is one of the leading causes of death worldwide, associated with our way of living and impacting all of society. In V|LF-Spiro3D, reference datasets are being acquired at standard MRI field to produce large sets of normative and training data covering six major respiratory diseases: asthma, chronic obstructive pulmonary diseases, bronchopulmonary dysplasia, cystic fibrosis, and bronchiolitis obliterans syndrome in transplant recipients. V|LF-Spiro3D will then redesign the current MRI architecture to perform 3D MR spirometry at low and very low field by highly-processed MRI throughout the lung while the patient is freely breathing, either lying, sitting, or standing in a light V|LF-MRI system. By prioritizing both technology transfer and innovation, V|LF-Spiro3D aims to build up a one-stop-shop imaging standard for the unrestricted assessment of lung pathophysiology.



3D MR spirometry datasets at standard field


3D MR spirometry post-processing workflow


Low- and very-low-field 3D MR spirometry


3D MR spirometry impact on patients’ experiences



Based on recent works at Universities Paris-Saclay and Aberdeen, in collaboration with leading MR manufacturer Siemens, SME NMR Service, major French-Dutch hospitals and patient organisations, V|LF-Spiro3D brings together multidisciplinary experts in a patient-oriented approach for both adults and children.


Things happening


the Fourier sphere

3D lung dynamic MRI sequentially acquire data in the reciprocal image space along an original adaptative radial trajectory of the Fourier sphere that can be randomly-ordered (AZTEK-shuffle), twisted (AZTEK-Twist), and accelerated (AZTEK-Speed)


For more about V|LF-Spiro3D

Xavier Maître
Scientific Coordinator
+33 6 64 35 63 98

Nicola Lorè
Project Manager
+33 6 99 88 65 31

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