Local gas flow-volume loops
Aims
V|LF-Spiro3D aims at developing and validating a new modality for spatially resolved, 3D lung structure and function characterization using cost-effective small-footprint, low and very-low MRI technology. 3D MR spirometry is to provide an accessible tool for the early diagnosis, staging, and treatment follow-up of patients suffering from respiratory diseases.
More
Lung function is a central concern in the fight against covid-19. Beyond the pandemic heavy losses and long-term health implications, respiratory diseases represent a major threat for the World Health Organisation. It is one of the leading causes of death worldwide, associated with our way of living and impacting all of society. In V|LF-Spiro3D, reference datasets are being acquired at standard MRI field to produce large sets of normative and training data covering six major respiratory diseases: asthma, chronic obstructive pulmonary diseases, bronchopulmonary dysplasia, cystic fibrosis, and bronchiolitis obliterans syndrome in transplant recipients. V|LF-Spiro3D will then redesign the current MRI architecture to perform 3D MR spirometry at low and very low field by highly-processed MRI throughout the lung while the patient is freely breathing, either lying, sitting, or standing in a light V|LF-MRI system. By prioritizing both technology transfer and innovation, V|LF-Spiro3D aims to build up a one-stop-shop imaging standard for the unrestricted assessment of lung pathophysiology.
Objectives
Acquire
3D MR spirometry datasets at standard field
Develop
3D MR spirometry post-processing workflow
Build
Low- and very-low-field 3D MR spirometry
Investigate
3D MR spirometry impact on patients’ experiences
CONSORTIUM
Partnerships
Based on recent works at Universities Paris-Saclay and Aberdeen, in collaboration with leading MR manufacturer Siemens, SME NMR Service, major French-Dutch hospitals and patient organisations, V|LF-Spiro3D brings together multidisciplinary experts in a patient-oriented approach for both adults and children.
LATEST
Things happening
Felipe Álvarez-Barrientos – PhD student at IPP
October 3rd, 2024 – Felipe Álvarez-Barrientos, PhD student at IPP Hi! I’m Felipe Álvarez-Barrientos, a PhD student at École Polytechnique working on the V|LF-Spiro3D project. I started my academic path
Quentin Herszkowicz – PhD student at UPSaclay
October 2nd, 2024 – Quentin Herszkowicz, PhD student at UPSaclay Hi, my name is Quentin ! I am a recently integrated PhD student, contributing to the European project V|LF-Spiro3D. I studied
Adrien Duwat – PhD student at UPSaclay
September 20th, 2024 – Adrien Duwat, PhD student at UPSaclay Exploring my journey in the V|LF-Spiro3D project Hey, I’m Adrien! I’m a PhD student working on the European V|LF-Spiro3D project.
2024 Banff-PITOR Joint Meeting
September 19th, 2024 – Banff-PITOR Joint Meeting A new dissemination activity for V|LF-Spioro3D! Philippe Grenier (Foch) joined the 2024 Banff-PITOR Joint Meeting in Paris. He presented the CT and MR quantitative methods
Introducing 3D MR Spirometry
September 4th, 2024 –Introducing 3D MR Spirometry – Exploring the Future of Pulmonary Function Testing: Introducing 3D MR Spirometry In the world of pulmonary testing, being able to accurately assess
First 3D dynamic images at Erasmus
July 2nd, 2024 – First 3D lung dynamic images at Erasmus Erasmus and UPSaclay had anticipated the implementation of the 3D UTE sequence on the Erasmus MRI system before the V|LF-Spiro3D project began. It was
Clinical research protocol at Foch Hospital
July 25, 2024 – Establishment of the first clinical research protocol at the Foch Hospital Amending on a start-up visit! With more than 1,000 transplants, Foch Hospital is France’s leading centre forlung
Setting up clinical research protocols
July 8, 2024 – Setting up clinical research protocols at Pitié-Salpêtrière and Bicêtre Hospitals Two set-up visits in one day! At 1 pm, UPSaclay and APHP met at the Cardiovascular
Breathing fresh air at Joliot seminar
July 11-12 2024 – Breathing fresh air at Joliot Summer seminar The Frédéric Joliot Institute of Life Sciences at the French Atomic Energy Commission (CEA) carries out original research in
Art-science at the digital health sector
V|LF-Spiro3D art-science at the core of digital health sector A colloquium on global health and local decisions. The French government’s digital transformation initiative aims to create a digital health sector to consolidate
Exploring
the Fourier sphere
3D lung dynamic MRI sequentially acquire data in the reciprocal image space along an original adaptative radial trajectory of the Fourier sphere that can be randomly-ordered (AZTEK-shuffle), twisted (AZTEK-Twist), and accelerated (AZTEK-Speed)
Contact
For more about V|LF-Spiro3D
Xavier Maître
Scientific Coordinator
xavier.maitre@universite-paris-saclay.fr
+33 6 64 35 63 98
Nicola Lorè
Project Manager
nicola.lore@universite-paris-saclay.fr
+33 6 99 88 65 31
