Reference 3D MR spirometry
Implement 3D MR spirometry at standard fields (1.5 T, 3 T).
Produce a reference database in healthy and diseased subjects.
We will optimise and implement 3D MR spirometry in the project clinical sites at standard fields (1.5 T, 3 T) to produce a world premiere database on adult and children healthy volunteers and patients covering major lung chronic pathologies (asthma, COPD, bronchiolitis obliterans syndrome, primary immunodeficiency, bronchopulmonary dysplasia, cystic fibrosis) and therapy follow-ups (lung transplantation, biotherapy, reversibility). We will perform standard pulmonary function tests for reference.
MR spirometry workflow
Investigate biomechanical models of the pulmonary function.
Search for new pathophysiologic determinants and biomarkers.
Develop 3D MR spirometry post-processing.
We will develop 3D MR spirometry post-processing deep learning techniques and investigate related biomechanical models of the pulmonary function. We will define multiple new parameters using 3D MR spirometry including isotropic metrics embedded in trajectories and local flow-volume loops (e.g. regional FEV1 and tidal volume, TD) and anisotropic ones like local strain and compliance. We will investigate new determinants and biomarkers of lung disease upon those produced by reference 3D MR spirometry at SF.
Low- and very-low-field 3D MR spirometry
Develop 3D MR spirometry at low and very-low fields.
Validate low- and very-low-field 3D MR spirometry.
We will build the instruments and design the methodologies to perform 3D MR spirometry acquisitions in the V|LF systems running in the academic laboratories (up to 0.1 T, 0.2 T, 0.55 T) as well as in the hospital (0.55 T). New RF coils, new pulse sequences, and new reconstruction algorithms will be developed for every VLF strength. The technique, including the workflow, will be validated on patients and healthy adults and children at LF (0.55 T). The imaging performances will also be proven in healthy adults at VLF (below 0.1 T).
3D MR spirometry economic, social, and humanistic investigation
Assess acceptance and adoption potential of 3D MR spirometry among practitioners and patients.
Grow awareness in the society and the industry to lung function.
We will assess the acceptance and adoption potential of the new technology among patients and practitioners in a broad transEuropean anthropological and philosophical perspective. We will ensure that the project results are efficiently exploited and communicated to the scientific and industrial communities, to the patients and to the public. We will make use of the scientific background and outcomes of the project in a behavioural art-science work to reveal the visitors’ breathing patterns.
Project management – Communication
Define, implement, and run collaborative management.
Manage risk, quality, and ethics.
Manage dissemination, exploitation, and communication.
The project will be managed through the following structure: A project board (PB) composed by one representative of each consortium partners The project coordinator (PC) (Xavier Maître, UPSaclay) ensures the executive role of the project The work package leader assembly (WPLA) groups the leaders of each work package The technology advisory board (TAB), composed by external contributors with relevant profile and expertise related to the technology to be developed, will provide advice to the project board. This task also consists in the proper management of administrative matters under the supervision of the administrative staff of UPSaclay and in compliance with EU rules.
To ensure compliance with the ‘ethics requirements’ set out in this work package.