First V|LF-Spiro3D publication!

August 8, 2025 – First V|LF-Spiro3D publication – European Radiology

Functional patterns of healthy human respiratory dynamics were ascertained by 3D MR spirometry as now published in European Radiology this month, on August 8th, 2025.

The challenge was not obvious. All of us breathe our own way. We all have a very personal lung morphology and a very personal way to use it – voluntarily or not – which varies over time. The first study on 25 healthy volunteers, carried over Nathalie Barrau’s PhD, has questioned the mere possibility to repeat and to reproduce 3D MR spirometry. Can a healthy baseline be established? upon which pathology can be discriminated? Just check the astounding diversity of the living on the animated 3D parametric map series below for tidal volume (TV), spontaneous peak expiratory flow (SPEF), spontaneous expiratory flow at 25% TV (SEF25), anisotropy deformation index (ADI).

The outcomes of the study have just been published in European Radiology: 3D MR spirometry exhibits shared respiratory features between individuals with gravity dependence. Intra-volunteer repeatability and global accuracy were found, demonstrating the reliability of the technique.

With spatial and feature scale normalisation, a new baseline is established for regional lung pathophysiology! Have a deeper look here: https://doi.org/10.1007/s00330-025-11838-0 and even deeper in Nathalie’s dissertation there: https://theses.hal.science/tel-04663088/.

Read the article here!