Title

3D MR spirometry in patients with bronchopulmonary dysplasia

Leading partner

Erasmus

Work Package

WP1

Sites

Erasmus MC-Sophia Children’s Hospital, Rotterdam, the Netherlands

Population

30 patients (15 girls and 15 boys) with BPD with different degrees of functional severity will be recruited prospectively within their annual follow-up program to undergo chest CT, spirometry and 3D MR spirometry on the same day.

Objectives

1. Validate 3D MR spirometry against spirometry in BPD patients
2. Validate 3D MR spirometry against chest-CT (performed as clinical follow-up at age of 7 years)
3. Assess the sensitivity of 3D MR spirometry to BPD severity
4. Assess the regional lung structural and functional changes with BPD severity using 3D MR spirometry
5. Evaluate the regional lung mechanics with respect to BPD severity using 3D MR spirometry
6. Establish reference flow-volume loop maps in BPD patients with 3D MR spirometry

Examination

All included patients will have spirometry, chest-CT and 3D MR spirometry performed the same day at Erasmus MC hospital. Spirometry will be performed in two positions (sitting and supine) and during two types of respiration (spontaneous and forced). Both CT and MRI scans will be acquired using a MR compatible spirometer to standardize lung volume and breathing manoeuvres.
3D MR spirometry will be performed on a 1.5 T MR imaging system (GE Healthcare) at Erasmus MC hospital. Patients will breath freely in a supine position during MR acquisition. Dynamic 3D lung images will be reconstructed by GE (WP1) and processed by UPSaclay (WP2) to primarily provide maps of flow-volume loops and maps of fractional anisotropy strain metric.