Title

Functional lung imaging at 0.55 T MRI using 3D MR spirometry and Fourier decomposition to assess pulmonary complications of primary immunodeficiency diseases

Leading partner

Foch

Work Package

WP3

Sites

Foch Hospital, Suresnes, France

Population

50 consecutive PID patients referred to MRI of the lung for chest surveillance of airways and lung parenchyma disorders.

Objectives

1. Validate 3D MR spirometry against spirometry in PID patients
2. Assess the regional lung structural and functional changes in airways and lung parenchyma in PID patients using 3D MR spirometry combined with morphological MR images.
3. Compare the regional functional changes assessed using 3D MR Spirometry with regional changes in lung perfusion and ventilation obtained by Fourier decomposition.

Examination

All included patients will have standard spirometry and LF 3D MR spirometry performed the same day at Foch hospital. Standard spirometry will be performed in two positions (sitting and supine) and during two types of respiration (spontaneous and forced). Dynamic 3D lung images will be reconstructed by Siemens and processed by UPSaclay to primarily provide maps of flow-volume loops and maps of fractional anisotropy strain metric. Three to four coronal and sagittal lung perfusion- and ventilation-weighted images will be provided through Fourier decomposition.