Title

Field cycling imaging and very-low-field 3D MR spirometry in healthy adults against gravity

Leading partner

Foch

Work Package

WP3

Sites

Biomedical Physics Building, Aberdeen, UK

Population

30 healthy adults (15 women and 15 men) will be recruited to undergo LF and VLF 3D MR spirometry.

Objectives

1. Validate LF and VLF 3D MR spirometry against simultaneous spirometry in healthy subjects
2. Assess the sensitivity of LF and VLF 3D MR spirometry to prone and supine positions
3. Assess the regional lung structural and functional changes with prone and supine positions using LF and VLF 3D MR spirometry
4. Evaluate the regional lung mechanics with respect to prone and supine positions using LF and VLF 3D MR spirometry
5. Establish flow-volume loop maps in healthy subjects with LF and VLF 3D MR spirometry
6. Compare flow-volume loop maps in healthy subjects with LF and SF 3D MR spirometry

Examination

MRI and FCI scans will be acquired using a MR-compatible spirometer for reference. 3D MR spirometry will be performed on a 0.1 T MR imaging system (Magnetec) and an FCI scanner (home-made) at the Biomedical Physics Building, University of Aberdeen. We will aim to have all scans done on the same day, but to avoid strain on the volunteers the MRI and FCI examinations may be done at most within a week. Subjects will breathe freely in prone and supine positions for 2 MR acquisitions in each scanner. Dynamic 3D lung images will be reconstructed and processed (WP2) by UPSaclay to primarily provide maps of flow-volume loops and maps of fractional anisotropy strain metric.