Title

3D MR spirometry in Lung Transplant Recipients with and without bronchiolitis obliterans syndrome

Leading partner

Foch

Work Package

WP1

Sites

Foch Hospital, Suresnes, France

Population

30 patients (15 women and 15 men) with BOS with different degrees of functional severity (5 for each grade 1, 2, 3), and 30 lung recipients without BOS (15 women and 15 men) will be recruited prospectively to undergo both standard spirometry and 3D MR spirometry.

Objectives

1. Validate 3D MR spirometry against spirometry in lung transplant recipients with and without BOS
2. Assess the sensitivity of 3D MR spirometry to BOS and to BOS severity
3. Assess the regional lung structural and functional changes with BOS severity and without BOS using 3D MR spirometry
4. Evaluate the regional lung mechanics with respect to BOS severity and without BOS using 3D MR spirometry
5. Establish reference flow-volume loop maps in LT patients with and without BOS with 3D MR spirometry

Examination

All included patients will have spirometry and 3D MR spirometry performed the same day at Foch hospital. Spirometry will be performed in two positions (sitting and supine) and during two types of respiration (spontaneous and forced).
3D MR spirometry will be performed on a 1.5 T MR imaging system (Siemens Healthineers) at Foch hospital. Patients will breath freely in supine position during MR acquisition. Dynamic 3D lung images will be reconstructed by Siemens (WP1) and processed by UPSaclay (WP2) to primarily provide maps of flow-volume loops and maps of fractional anisotropy strain metric.