Title

3D MR Spirometry in adults with severe asthma before and after biotherapy

Leading partner

UPSaclay

Work Package

WP1

Sites

Bicêtre Hospital, Le Kremlin-Bicêtre, France

Population

30 adults (15 women and 15 men) with asthma to undertake biotherapy will be recruited prospectively within their follow-up program to undergo spirometry and 3D MR spirometry on the same day before and after biotherapy

Objectives

1. Validate 3D MR spirometry against spirometry in adults with asthma
2. Assess the regional lung structural and functional changes and mechanics in adults with asthma before and after biotherapy using 3D MR spirometry
3. Investigate the mechanical properties of the (asthmatic) lung
4. Investigate the effect of biotherapy and the mechanical properties of the lung

Examination

All included patients will have spirometry and 3D MR spirometry performed the same day at Bicêtre Hospital. Spirometry will be performed in two positions (sitting and supine) and during three types of respiration (spontaneous, slow, and forced). MRI scans will be acquired using a MR compatible spirometer for reference.
3D MR spirometry will be performed on a 1.5 T MR imaging system (Siemens Healthineers) at Bicêtre Hospital. Patients will breath freely in a supine position during MR acquisition. Dynamic 3D lung images will be reconstructed (WP1) and processed (WP2) by UPSaclay to primarily provide maps of flow-volume loops and maps of fractional anisotropy strain metric.